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1

Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

Stange, Daniel E., Koo, Bon-Kyoung, Huch, Meritxell, Sibbel, Greg, Basak, Onur, Lyubimova, Anna, Kujala, Pekka, Bartfeld, Sina, Koster, Jan, Geahlen, Jessica H., Peters, Peter J., van Es, Johan H., va

Journal:

Year:

2013

Language:

english

File:

PDF, 4.33 MB

english, 2013

2

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

Turner, Martin, Joseph Mee, P., Costello, Patrick S., Williams, Owen, Price, Abigail A., Duddy, Linda P., Furlong, Michael T., Geahlen, Robert L., Tybulewicz, Victor L. J.

Journal:

Year:

1995

File:

PDF, 1.08 MB

1995

3

Effect of phosphorylation of ovalbumin on adsorption by aluminum-containing adjuvants and elution upon exposure to interstitial fluid

Garry L. Morefield, Dongping Jiang, Ilia Z. Romero-Mendez, Robert L. Geahlen, Harm HogenEsch, Stanley L. Hem

Journal:

Year:

2005

Language:

english

File:

PDF, 133 KB

english, 2005

4

Hierarchy of Protein Tyrosine Kinases in Interleukin-2 (IL-2) Signaling: Activation of Syk Depends on Jak3; However, Neither Syk nor Lck Is Required for IL-2-Mediated STAT Activation

Zhou, Y.-J., Magnuson, K. S., Cheng, T. P., Gadina, M., Frucht, D. M., Galon, J., Candotti, F., Geahlen, R. L., Changelian, P. S., O'Shea, J. J.

Journal:

Molecular and Cellular Biology

Year:

2000

Language:

english

File:

PDF, 1.05 MB

english, 2000

5

In-depth Analyses of Kinase-dependent Tyrosine Phosphoproteomes Based on Metal Ion-functionalized Soluble Nanopolymers

Iliuk, A. B., Martin, V. A., Alicie, B. M., Geahlen, R. L., Tao, W. A.

Journal:

Molecular & Cellular Proteomics

Year:

2010

Language:

english

File:

PDF, 675 KB

english, 2010

6

Mechanisms of p34cdc2 regulation.

Atherton-Fessler, S, Parker, L L, Geahlen, R L, Piwnica-Worms, H

Journal:

Molecular and Cellular Biology

Year:

1993

Language:

english

File:

PDF, 2.51 MB

english, 1993

7

The engagement of β1 integrins on promonocytic cells promotes phosphorylation of Syk and formation of a protein complex containing Lyn and β1 integrin

Lesley A. Miller, Julie J. Hong, Michael S. Kinch, Marietta L. Harrison, Robert L. Geahlen

Journal:

European Journal of Immunology

Year:

1999

Language:

english

File:

PDF, 124 KB

english, 1999

8

Synthesis of myristoyl CoA analogues and myristoyl peptides as inhibitors of myristoyl CoA: Protein N-myristoyltransferase

Guo-Qiang Zheng, Xiufeng Hu, John M. Cassady, Lisa A. Paige, Robert L. Geahlen

Journal:

Journal of Pharmaceutical Sciences

Year:

1994

Language:

english

File:

PDF, 877 KB

english, 1994

9

Detection of protein kinase activity in sodium dodecyl sulfate-polyacrylamide gels

Robert L. Geahlen, Michael Anostario Jr., Philip S. Low, Marietta L. Harrison

Journal:

Analytical Biochemistry

Year:

1986

Language:

english

File:

PDF, 2.27 MB

english, 1986

10

Detection of myristoyl CoA:protein N-myristoyltransferase activity by ion-exchange chromatography

Lisa A. Paige, David R. Chafin, John M. Cassady, Robert L. Geahlen

Journal:

Analytical Biochemistry

Year:

1989

Language:

english

File:

PDF, 500 KB

english, 1989

11

Immunochemical detection of adenine nucleotide-binding proteins with antibodies to 5′-p-fluorosulfonylbenzoyladenosine

Michael Anostario Jr., Marietta L. Harrison, Robert L. Geahlen

Journal:

Analytical Biochemistry

Year:

1990

Language:

english

File:

PDF, 1.79 MB

english, 1990

12

Modeling and analysis of early events in T-lymphocyte antigen-activated intracellular-signaling pathways

Yanan Zheng, Venkataramanan Balakrishnan, Greg Buzzard, Robert Geahlen, Marietta Harrison, Ann Rundell

Journal:

Journal of Computational and Applied Mathematics

Year:

2005

Language:

english

File:

PDF, 378 KB

english, 2005

13

Synthesis and evaluation of new protein-tyrosine kinase inhibitors. Part 2. Phenylhydrazones.

Mark Cushman, Dhanapalan Nagarathnam, D. Gopal, Robert L. Geahlen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1991

Language:

english

File:

PDF, 240 KB

english, 1991

14

Synthesis and evaluation of new protein-tyrosine kinase inhibitors. Part 1. pyridine-containing stilbenes and amides.

Mark Cushman, Dhanapalan Nagarathnam, D. Gopal, Robert L. Geahlen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1991

Language:

english

File:

PDF, 277 KB

english, 1991

15

Synthesis of a series of brominated 1-phenyl-2-pyridylethenes as inhibitors of the protein-tyrosine kinase p56lck

Hu-Ming He, Robert L. Geahlen, Mark Cushman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 286 KB

english, 1994

16

Proteomic Studies of Syk-Interacting Proteins Using a Novel Amine-Specific Isotope Tag and GFP Nanotrap

Jacob A. Galan, Leela L. Paris, Hua-jie Zhang, Jacob Adler, Robert L. Geahlen, W. Andy Tao

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2011

Language:

english

File:

PDF, 367 KB

english, 2011

17

A general method for preparation of peptides biotinylated at the carboxy terminus

Robert L. Geahlen, G. Marc Loudon, Lisa A. Paige, David Lloyd

Journal:

Analytical Biochemistry

Year:

1992

Language:

english

File:

PDF, 371 KB

english, 1992

18

The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells

Zhou, Q, Geahlen, R L

Journal:

Year:

2009

Language:

english

File:

PDF, 411 KB

english, 2009

19

Molecular interdiction of Src-family kinase signaling in hematopoietic cells

Geahlen, Robert L, Handley, Misty D, Harrison, Marietta L

Journal:

Year:

2004

Language:

english

File:

PDF, 414 KB

english, 2004

20

Two Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with Vav

Chen, C.-H., Martin, V. A., Gorenstein, N. M., Geahlen, R. L., Post, C. B.

Journal:

Molecular and Cellular Biology

Year:

2011

Language:

english

File:

PDF, 1.85 MB

english, 2011

21

Signal transduction between red cells and other blood cells

Philip S. Low, Qing Li, Anatoly Kiyatkin, Prema Rathinavelu, Robert L. Geahlen, Marietta L. Harrison

Journal:

Year:

1995

Language:

english

File:

PDF, 205 KB

english, 1995

22

Properties of a tyrosine protein kinase from calf thymus. Response to ionic strength and divalent cations

David L. Mason, Marietta L. Harrison, Robert L. Geahlen

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1985

Language:

english

File:

PDF, 637 KB

english, 1985

23

Identification of reactive oxygen intermediate responsive tyrosine kinases in lymphocytes

Gary L. Schieven, Jean M. Kirihara, Robert L. Geahlen, Jeffrey A. Ledbetter

Journal:

Free Radical Biology and Medicine

Year:

1993

Language:

english

File:

PDF, 148 KB

english, 1993

24

The microtubule-associated protein tau is phosphorylated by Syk

Thibaud Lebouvier, Timothy M.E. Scales, Diane P. Hanger, Robert L. Geahlen, Bernard Lardeux, C. Hugh Reynolds, Brian H. Anderton, Pascal Derkinderen

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2008

Language:

english

File:

PDF, 347 KB

english, 2008

25

Syk and pTyr'd: Signaling through the B cell antigen receptor

Robert L. Geahlen

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2009

Language:

english

File:

PDF, 464 KB

english, 2009

26

The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2

Kyung D. Moon, Xiaoying Zhang, Qing Zhou, Robert L. Geahlen

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2012

Language:

english

File:

PDF, 572 KB

english, 2012

27

Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores

Victoria A. Martin, Wen-Horng Wang, Andrew M. Lipchik, Laurie L. Parker, Yantao He, Sheng Zhang, Zhong-Yin Zhang, Robert L. Geahlen

Journal:

Cellular Signalling

Year:

2012

Language:

english

File:

PDF, 972 KB

english, 2012

28

The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling

Ibrahim Y. Hawash, X.Eric Hu, Adiam Adal, John M. Cassady, Robert L. Geahlen, Marietta L. Harrison

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2002

Language:

english

File:

PDF, 269 KB

english, 2002

29

Synthesis of [β-(4-pyridyl-1-oxide)-L-alanine4]-angiotensin I as a potential suicide substrate for protein-tyrosine kinases

MARK CUSHMAN, PENNAMUTHIRIAR CHINNASAMY, ASIT K. CHAKRABORTI, JURJUS JURAYJ, ROBERT L. GEAHLEN, RUDIGER D. HAUGWITZ

Journal:

Chemical Biology & Drug Design

Year:

1990

Language:

english

File:

PDF, 491 KB

english, 1990

30

Selective Inhibition of the Growth of ras-Transformed Human Bronchial Epithelial Cells by Emodin, a Protein-Tyrosine Kinase Inhibitor

T.C.K. Chan, C.J. Chang, N.M. Koonchanok, R.L. Geahlen

Journal:

Biochemical and Biophysical Research Communications

Year:

1993

File:

PDF, 364 KB

1993

31

Posttranslational acylation of the transferrin receptor in LSTRA cells with myristate, palmitate and stearate: Evidence for distinct acyltransferases

Monica J.S. Nadler, X.Eric Hu, John M. Cassady, Robert L. Geahlen

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1994

Language:

english

File:

PDF, 794 KB

english, 1994

32

Piceatannol (3,4,3′,5′-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor

Robert L. Geahlen, Jerry L. McLaughlin

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 295 KB

english, 1989

33

Identification of tyrosine 67 in bovine brain myelin basic protein as a specific phosphorylation site for thymus p56lck

Qingmei Wang, Jean B. Smith, Marietta L. Harrison, Robert L. Geahlen

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 1.76 MB

english, 1991

34

Synthesis of a Phosphoserine Mimetic Prodrug with Potent 14-3-3 Protein Inhibitory Activity

Allison Arrendale, Keunho Kim, Jun Young Choi, Wei Li, Robert L. Geahlen, Richard F. Borch

Journal:

Chemistry & Biology

Year:

2012

Language:

english

File:

PDF, 607 KB

english, 2012

35

Structural Basis for the Requirement of Two Phosphotyrosine Residues in Signaling Mediated by Syk Tyrosine Kinase

Teresa D. Groesch, Fei Zhou, Sampo Mattila, Robert L. Geahlen, Carol Beth Post

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 778 KB

english, 2006

36

The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage

Andrew J. Bredemeyer, Jessica H. Geahlen, Victoria G. Weis, Won Jae Huh, Bernd H. Zinselmeyer, Subhashini Srivatsan, Mark J. Miller, Andrey S. Shaw, Jason C. Mills

Journal:

Developmental Biology

Year:

2009

Language:

english

File:

PDF, 3.47 MB

english, 2009

37

Detection of a novel lymphocyte protein-tyrosine kinase by renaturation in polyacrylamide gels

Robert L. Geahlen, Marietta L. Harrison

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 1021 KB

english, 1986

38

Phosphorylation of glycogen synthase by a bovine thymus protein-tyrosine kinase, p40

Alan M. Mahrenholz, Philip Votaw, Peter J. Roach, Anna A. Depaoli-Roach, Thomas F. Zioncheck, Marietta L. Harrison, Robert L. Geahlen

Journal:

Biochemical and Biophysical Research Communications

Year:

1988

Language:

english

File:

PDF, 440 KB

english, 1988

39

Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk

Michael T Furlong, Alan M Mahrenholz, Ki-Han Kim, Curtis L Ashendel, Marietta L Harrison, Robert L Geahlen

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1997

Language:

english

File:

PDF, 354 KB

english, 1997

40

Inhibition of β2 Integrin Receptor and Syk Kinase Signaling in Monocytes by the Src Family Kinase Fgr

Charlotte M Vines, Jeffrey W Potter, Yin Xu, Robert L Geahlen, Patrick S Costello, Victor L Tybulewicz, Clifford A Lowell, Peter W Chang, Hattie D Gresham, Cheryl L Willman

Journal:

Year:

2001

Language:

english

File:

PDF, 663 KB

english, 2001

41

Unexpected Effects of FERM Domain Mutations on Catalytic Activity of Jak3: Structural Implication for Janus Kinases

Yong-Jie Zhou, Min Chen, Nancy A. Cusack, Lida H. Kimmel, Kelly S. Magnuson, James G. Boyd, Wen Lin, Joseph L. Roberts, Andrea Lengi, Rebecca H. Buckley, Robert L. Geahlen, Fabio Candotti, Massimo Gad

Journal:

Year:

2001

Language:

english

File:

PDF, 627 KB

english, 2001

42

Cloning and expression of a protein-tyrosine-phosphatase.

Guan, K. L., Haun, R. S., Watson, S. J., Geahlen, R. L., Dixon, J. E.

Journal:

Proceedings of the National Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 1.38 MB

english, 1990

43

A Novel Quantitative Proteomics Strategy To Study Phosphorylation-Dependent Peptide−Protein Interactions

Zhou, Fei, Galan, Jacob, Geahlen, Robert L., Tao, W. Andy

Journal:

Journal of Proteome Research

Year:

2007

Language:

english

File:

PDF, 298 KB

english, 2007

44

Phosphorylation of cAMP-dependent protein kinase subunits

Robert L. Geahlen, David F. Carmichael, Eikichi Hashimoto, Edwin G. Krebs

Journal:

Advances in Enzyme Regulation

Year:

1982

Language:

english

File:

PDF, 697 KB

english, 1982

45

XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic Reticulum

Won Jae Huh, Emel Esen, Jessica H. Geahlen, Andrew J. Bredemeyer, Ann–Hwee Lee, Guanglu Shi, Stephen F. Konieczny, Laurie H. Glimcher, Jason C. Mills

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 4.10 MB

english, 2010

46

Tamoxifen Induces Rapid, Reversible Atrophy, and Metaplasia in Mouse Stomach

Won Jae Huh, Shradha S. Khurana, Jessica H. Geahlen, Kavita Kohli, Rachel A. Waller, Jason C. Mills

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 6.62 MB

english, 2012

47

Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogs of piceatannol

Thakkar, Kshitij, Geahlen, Robert L., Cushman, Mark

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 914 KB

english, 1993

48

Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogs

Cushman, Mark, Nagarathnam, Dhanapalan, Burg, Debra L., Geahlen, Robert L.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 1.22 MB

english, 1991

49

Protein-Tyrosine Kinase Inhibition: Mechanism-Based Discovery of Antitumor Agents

Chang, Ching-Jer, Geahlen, Robert L.

Journal:

Journal of Natural Products

Year:

1992

Language:

english

File:

PDF, 1.63 MB

english, 1992

50

Design and Synthesis of Phosphotyrosine Peptidomimetic Prodrugs

Garrido-Hernandez, Hugo, Moon, Kyung D., Geahlen, Robert L., Borch, Richard F.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 147 KB

english, 2006